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Your Position: Home > C-Reactive Protein

C-Reactive Protein

Brief Information

Name:C-reactive protein
Target Synonym:CRP,C-Reactive Protein, Pentraxin-Related,Pentraxin 1,PTX1,C-reactive protein
Number of Launched Drugs:0
Number of Drugs in Clinical Trials:1
Lastest Research Phase:NDA/BLA

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Cat. No. Species Product Description Structure Purity Feature
CRP-H82E4 Human Biotinylated Human C-Reactive Protein (CRP), His,Avitag™ (MALS verified)
CRP-H82E4-structure
CRP-H82E4-sds
CRP-H5226 Human Human C-Reactive Protein (CRP) Protein, His Tag
CRP-H5226-structure
CRP-H5226-sds
ACRO Quality

Part of Bioactivity data

CRP-H82E4-MALS-HPLC
C-Reactive Protein MALS images

The purity of Biotinylated Human C-Reactive Protein, His,Avitag (Cat. No. CRP-H82E4) is more than 90% and the molecular weight of this protein is around 145-167kDa verified by SEC-MALS.

CRP-H82E4-ELISA
C-Reactive Protein ELISA

Immobilized Human CD32a (H167), His Tag (Cat. No. CD1-H5223) at 5 μg/mL (100 μL/well) can bind Biotinylated Human C-Reactive Protein, His,Avitag (Cat. No. CRP-H82E4) with a linear range of 0.02-1.25 μg/mL (QC tested).

Protocol

Synonym Name

CRP,C-reactive Protein

Background

C-reactive protein (CRP) is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat respectively. CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP participates in the clearance of necrotic and apoptotic cells. CRP rises up to 50,000-fold in acute inflammation, such as infection. It rises above normal limits within 6 hours, and peaks at 48 hours. Its half-life is constant, and therefore its level is mainly determined by the rate of production. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

Clinical and Translational Updates

Clinical Drug Information

Name Research Code Research Phase Company Indications Clinical Trials
ISIS-329993 ISIS-CRP; ISIS-329993; ISIS-CRPRx Ionis Pharmaceuticals Inc Details

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